Visas: All visitors to Equatorial Guinea require a visa, which is usually valid for 30 days. In Africa, the easiest places to get a visa are Cameroon and Gabon, though it's not very difficult anywhere with same-day service the norm.
Health risks: You will require immunizations (and, often, proof of this) against yellow fever, cholera, tetanus, typhoid, meningitis, polio and hepatitis A. You'll also need to guard against giardia, dysentry, fungal infections, rabies, tuberculosis, bilharzia, diptheria, malaria, typhus and a whole textbook of other water-, insect- and air-borne diseases.

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